Our Scholars

Year Recruited:

2023 2022 2021 2020 2019 2018 2017 2016 2015 2012 2011 2010 2009 2008 2006 2005 2004 2003 2000 1999 1998
Year Recruited: 2023
( 3 Scholars )

Herman Fung, PhD

European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
Affiliation(s):
Cell and Developmental Biology, Life Sciences Institute
Research Interests

Advances in cryo-electron tomography (cryo-ET), including cryo-focused ion beam (FIB) milling for the thinning of cells and new cryo-TEM instrumentation, allow the visualization of molecular sociology inside cells in near-native state.

Sarah Kargbo-Hill, Ph.D.

Yale University
Affiliation(s):
Molecular, Cellular and Developmental Biology
Research Interests

The Kargbo-Hill lab is interested in how neurons reshape their epigenomic and transcriptomic architecture in conditions of stress, aging, and neurodegenerative disease. In particular, the lab focuses on two mechanisms of neuronal gene regulation – RNA splicing and DNA methylation. We are interested in how these processes are specialized in neurons and how they become altered in contexts of aging and disease. By understanding how neurons process and actualize change, we can gain insight into neuronal resilience and vulnerability in neurodegenerative disease

Paul Kramer, Ph.D.

The Vollum Institute, Oregon Health and Science University
Affiliation(s):
Molecular, Cellular and Developmental Biology
Research Interests
Our lab researches the neurophysiology of axonal signaling, and how axonal signal impacts the development of substance use disorders. The axon is the thinnest structure that emerges from a neuron but it can sometimes account for the vast majority of the neuronal membrane because of how long axons are. Therefore, changes to axonal physiology can have dramatic effects on the function and output of the cell. Axons are well known for propagating action potentials, but emerging research shows they can also signal actively from one axon to another and can even initiate action potentials locally, a non-canonical method for signal transmission in the nervous system as it does not involve somatodendritic processing. These recent data force us to reevaluate what roles axons can have in neuronal physiology, and open the door for future research in axonal neurobiology. Our lab will expand our understanding on this topic, together with an exploration of how nicotine and alcohol use disorders impact the function of axonal signaling and how axonal signaling impacts the development of these neurological disorders.

 

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