Jorge Iñiguez-Lluhi, Ph.D.
The focus of research in our lab is to gain fundamental mechanistic understanding of the basic mechanisms of transcription, the molecular basis of specific functional interactions among transcription factors and how these elements of genomic regulatory logic are assembled to give rise to complex patterns of gene expression in an intact developing tissue.
Thomas Wilson, M.D., Ph.D.
The goal of our laboratory is to gain insight into the molecular basis of chromosomal rearrangement in cancer by systematically identifying both enzymatic and structural components of the DNA double-strand break (DSB) repair mechanisms and characterizing how these (and deficiencies therein) interact to achieve the sequence of biochemical events resulting in repair (or rearrangement). This is done primarily using novel assays developed in the genetically tractable model organism Saccharomyces cerevisiae, since it is now clear that the fundamental mechanisms of DSB repair are preserved in all eukaryotes.