Ryan Baldridge, Ph.D.
Ryan will study basic mechanisms of membrane-bound protein-quality control systems. He plans to determine how membrane-bound systems select substrates to identify cellular pathways regulated by these systems (including ERAD). These systems are important in pathologies related to cell stress, protein misfolding, and protein misregulation. Some of the human conditions linked to these problems include Parkinson’s disease, Alzheimer’s disease, and various cancers. His long-term goals are to define mammalian pathways regulated by membrane-bound quality control systems to understand how changing conditions target substrate proteins to these systems. Eventually, he would like to develop a screening platform to identify activators and inhibitors of these various quality control systems. Understanding these systems using novel assays should allow screening for, and refinement of, therapeutics with value in a wide range of pathologies.
Michael Cianfrocco, Ph.D.
We are a research team that is trying to understand the molecular details that determine how, where, and when motor proteins transport intracellular cargo. The past thirty years of cell biology research have set the stage for us to determine the general principles that underlie the complex process of intracellular transport.
Our lab focuses on the structural biology and biophysics underlying microtubule-based intracellular transport, defects in which can result in neurodevelopmental and neurodegenerative diseases. The lab uses a combination of high-resolution cryo-EM and single-molecule techniques to investigate transporting of motor-cargo complexes.