Asim Beg, Ph.D.
Our lab studies the molecular and cellular mechanisms underlying neuronal circuit assembly and function. We are particularly interested in understanding how the central nervous system controls movement from both physiological and behavioral perspectives.
Ken Inoki, M.D., Ph.D.
The Inoki lab studies the role of mammalian target of rapamycin (mTOR) signaling in the development of cancer and metabolic disorders such as diabetes using mouse models. Our lab also investigates the molecular mechanisms by which mTOR pathway is regulated by extra- and intracellular cues using cell biology, biochemical, and genetic approaches.
David Lombard, M.D., Ph.D.
Aging is a conserved but poorly understood biological phenomenon. In invertebrates, overexpression of sirtuins – homologs of the yeast Sir2 deacetylase – confers increased lifespan. Mammals possess seven sirtuins, called SIRT1-SIRT7. Many of these proteins modulate metabolic processes. Our group focuses on the mitochondrial sirtuin SIRT3 and the nuclear sirtuin SIRT6. We are attempting to elucidate links between these sirtuins and metabolism, cancer, and aging.
Carey Lumeng, M.D., Ph.D.
Our laboratory is interested in how inflammatory cells and pathways are activated in obesity and how this leads to diseases such as type 2 diabetes and metabolic syndrome. We utilize animal models, cell biology, and biochemistry techniques to understand how inflammatory cells in fat are recruited to adipose tissue and how this contributes to metabolic diseases. The lab is focused on understanding the biology of adipose tissue macrophages, a novel type of inflammatory cell that invades fat with obesity and alters the normal function of adipose tissue.
Marina Pasca di Magliano, Ph.D.
My laboratory studies the formation and progression of pancreatic cancer. The onset of pancreatic cancer is characterized by activation of signaling pathways that are quiescent in the normal pancreas. We are in particular interested in the Hedgehog signaling pathway, that acts in a paracrine manner to mediate the interaction of tumor cells with their surrounding microenvironment (or tumor stroma). Our long-term goal is to target tumor-stroma interactions for the treatment of pancreatic cancer.
Bing Ye, Ph.D.
We study how distinct subcellular compartments are established in neurons and how this process contributes to the organization of the nervous system. We are particularly interested in the differential development between dendrites and axons and the strategic distribution of synapses in subcellular compartments. We employ a multi-disciplinary approach, including genetics, molecular biology, biochemistry, and advanced multi-dimensional imaging, to study these problems in both Drosophila and mammals.